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34 Cards in this Set

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alkylating agents?
busulfan (Myleran)

cyclophosphamide (Cytooxan)

ifosfamide (Ifex)
platinum analogues?
carboplatin (Paraplatin)

cisplatin (Platinol)
SE of cyclophosphamide?
hemorrhagic cystitis: dose-related, due to formation of acrolein to prevent give mesna (binds to acrolein) and hydrate
Use of cyclophosphamide?
neoplastic (RA, glomerular nephritis, idiopathic thrombocytopenic purpura) and non-neoplastic (breast, ovarian, prostate, lung)
SEs of oncology drugs?
CNS2, GI2, BMS- R, W, T, some alopecia, mucusitis, entagenic
what can ifosfamide (Ifex) cause?
acrolein metabolite, so give MESNA and hydrate
SEs of ifosfamide (Ifex)
hemorrhagic cystitis
CNS2: once experience CNS toxicity (lethargy, fatigue), d/c drug
antibiotic for oncology
bleomycin (SE: pulmonary fibrosis)
SE: pulmonary fibrosis
bleomycin
busulfan
amiodarone
nitrofurantoin
SE: cisplatin
nephro and ototoxicity (like aminoglycosides), prevent with hydration and amifostine
anthracyclines:
daunorubicin (Cerbidine)
doxorubicin (Adriamycin)
idarubicin (Idamycin)
Cerbidine
daunorubicin
Idamycin
idarubicin
Adriamycin
doxorubicin
Myleran
busulfan
Cytoxan
cyclophosphamide
SE of anthracycline:
cardiac toxic: give Zenicard (desrazasone)
use of anthracycline:
breast, ovarian, leukemias
lifetime dose of daunorubicin, doxorubicin:
550mg/m2
lifetime max dose of idarubicin:
137.5 mg/m2
dose of daunorubicin (Cerbidine):
60 mg/m2
dose of doxorubicin (Adriamycin)
12 mg/m2
desrazoxane
used to prevent cardiotoxcitiy in pts on anthracyclines

Zinecard
antimetabolites
methotrexate (Amethopterin)
cytarabine (Cytosar) (Ara-C)
high dose of methotrexate?
1 g/m2
uses of methotrexate:
solid tumors, lymphomas, RA, psoriasis
give what with MTX?
leucovorin- if not mucosal damage in GI tract and irrerversible BMS- R, W

dose: 10-100 mg/m2 q6h until MTX levels fall
MTX will cause:
irreversible BMS: R, W if no leucovorin rescue along with GI mucosal damage
SE of cytarabine (Cytosar):
conjunctivits : will need corticosteroid eye drops
CNS1: slurring, forgetfulness
most likely to cause mucositis:
MTX, Ara-C (cytarbine), 5-FU, anthracyclines, bleomycin
highly ematogenic 60-100%:
cisplatin, cyclophosphamide, Ara-C (cytarabine), MTX: give 5-HT3 antagonist
moderately ematogenic 10-60%
anthracyclines, carbaplatin: can give Reglan and dexamethasone
low ematogenic <10%:
bleomycin, busulfan, low dose MTX: give Phenergan and go up from there
MOA of Zofran
selectively antagonizes 5HT-3 receptors