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50 Cards in this Set

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Vancomycin
IV. against G+ organisms. inhibits cell wall synthesis.
Linezolid
Zyvox. resistant G+ organisms. blocks protein synthesis in new spot (blocks assembly of ribosomes). bacteriostatic
Daptomycin
Cubicin. for resistant G+. binds to plasma membrane. bacteriocidal
Natamycin
Natacyn - Antifungal. binds to sterols in cell membrane, creating pores. broad spectrum.
Amphotericin B
Fungizone. antifungal. creates pores. broad spectrum.

Toxicity: reversible renal damage, hypotension, vomiting.
Nystatin
Mycostatin - antifungal. binds to sterols, pores. broad spectrum.

Tox: nausea, vomitting, blood disorders, renal damage
Miconazole
Monistat. antifungal. inhibits P450 enzymes. broad with effect on G+ bacteria.

Tox: low tox. SPK. systemic admin: nasua, fever, anorexia, anemia..

Other imidazoles/triazoles: ketoconazole (nizoral), clotrimazole (lotrimin), fluconazole (diflucan), fluconazole
Other name for Linezolid
Zyvox
Other name for Daptomycin
Cubicin
Other name for Natamycin
Natacyn
Other name for Amphotericin B
Fungizone
Other name for Nystatin
Mycostatin
Other name for Miconazole
Monistat
Othername for Flucytosine
5-flucorocytosine
Flucoytosine
antifungal. disrupts normal rna/dna syntehsis. esp effective in yeast. effective with amphetericin B.

Tox: severe, includes myelosuppression. (bone marrow suppression)
Griseofulvin
inhibits fungal mitosis. effective in dermatophytes. takes long time to work. no ocular use

Tox: oral: H/A, lethargy, confusion, nausea, vomitting, bad taste, blood disorders, photosensitivty
General Toxicities of Antivirals
Common: stomatits (mouth inflam), anorexia, nausea, vomitting

Occational: alopecia (hair loss), blood dyscrasias, blood marrow depression, kidney/liver impairment, convulsions
Rare: insomnia, depression, dizziness
Idoxuridine
antiviral. Best against HSV1. nucleotide analog of deoxy-thymidine. needs thymidine kinase to phosphorylate to triphosphate. not oral. MOA: inhibition of several enzymes in DNA synth & incorporation of IDUTP.

Tox: pain, photophobia, edema of lids, keratopathy, limbal follicles, ptosis, allergic reactions, punctal stenosis.
Other name of Vidarabine
Vira-A
Vidarabine
anti-viral. ointment. analog of adenosine. inhibits DNA pol, incorp. into viral DNA.
Other name of Trifluridine
Viroptic
Trifluridine
antiviral. thymidine analog. same MOA as others. selectivity with dose dependent HSV I, II and vaccinia.

no cross-resistance/sensitivty. better penetration.

Tox: less frequent. stinging/burning, lid edema, conj. hypermia, chemosis, keratitis, corneal edema. decreased corneal healing, punctal occlusion. IV or topic.
Other name for Acyclovir
Zovirax
Acyclovir.
antiviral. HSV I & II, VZV. deoxy-guanosine derivativbe. highly selective. stop recourance.

MOA: preferential phosphylation of virus, inhibition of viral dna pol, incorporation.

Tox: burning, stinging, SPK. nausea, vomitting diarrhea, H/A., rash. healing not supressed.
Other name of Famciclovir
Famvir
Other name of Valacyclovir
Valtrex
Ganciclovir
CMV retinitis. toxic to normal cells. IV or oral.

Tox: RD, bone marrow depress, granulocytopenia, thrombocytopenia.
Cidofovir
similar to ganciclovir.

Tox: nephrotoxicity, proteinuriea, increased creatinine, nausea vomitting, diarrhea, anorexia, ab pain, hair loss, rash, fever, anemias, amblyopia, conjuctivitis, hypotony.
Other name of Ganciclovir gel
Zirgan
Ganciclovir Gel
for acute herpatic keratitis.

Tox: blurred vision, irritation, SPK, conj. hpermia.
Foscarnet
for Aids patients with CMV retinitis. inhibits DNA pol and reverse transcriptse. no need for phosphorylation. IV.

Tox: frequent, decreased renal function. bone marrow suprresion, fever, nausea, anemia, diarrhea, vomitting, HA, seizures.
Other name of Fomivirsen
Vitravene
Fomivirsen
for CMV retinitis. antisense agent, blocks expression of 2 viral proteins. binds to mRNA.

Tox: similar toxicities. iritis, increased IOP, vitritis, cataracts.
Amatadine
anti-influenza. oral. Prophylactic for influenza A (not B). MOA: inhibit uncoating of virus (interferes with viral protein M2).

Tox: blurred visions, hallucinations, confusion, anxiety, dizziness, orthostatic hypotension, depression, psychosis and CHF. increase actions of anticholigergics.
Rimatidine
Similar to Amantidine
Zanamivir
inhaled inhibitor of viral release (neuraminidase). A & B. Bronchosmasm
Oseltamivir
same as Zanamivir. inhaled inhibitor of viral release (neuraminidase). A can cause nausea.
Name 3 Nucleoside RT inhibitors
Retrovir, Hivid, Videx
Nucleotide reverse transcriptor inhibitors
must be triphosphorylated. inhibit reverse transcriptase.

Tox: bone marrow depression, neuropathy, pncreatitis. insomnia, nausea, HA.
Non-nucleoside RT inhibitors
no need to be phosphorylated. alter enzyme conformation. good for HIV-1. restistance rapid.

Tox: rash, HA, less frequent hepatits.
Name 2 Non-nucleoside RT inhibitors
Viramune, Rescriptor
Protease inhibitors
inhibition of enzyme to cleave viral polyprotein precursors. stops it from cleaving into parts to leave cell.

Tox: Nausea, vomitting, diarrhea, paresthesias. fatal interaction with AR, AC, benzo's
Name 3 Protease Inhibitors
Norvir, Crixivan, Invirase
Fuzeon
newest fusion inhibitor. binds to GP41, prevents conformational change. injected.

Tox: pain, redness, nodules, cysts. Eosinophillia, bacteria pneumonia.
Fusion Inhibitors
Fuzeon, Selzentry
Selzentry
oral, blocks entry of HIV

Tox: cough, fever, dizziness, HA, low BP, nausea, bladder irritation
Integrase Inhibitors
blocks ability of integration of HIV DNA into human DNA.

Tox: Diarrhea, nausea, HA, fever
Name Integrase Inhibitor
Raltegravir
Catabolic Actions of Cortisol
carb, protein, lipid metabolism.
MOA of Amantadine and Rimantidine
prevents uncoating of virus and interfere with viral assembly. stops viral protein M2