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27 Cards in this Set

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Pluripotent
small mononuclear cells
-self-perpetuating
-forms colonies (CFU)
Multipotent
can differentiate into lymphoid or myeloid cells
Progenitor cells
committed a cell lineage. developmental restriction, allows tremendous amplification
Precursor cells
can proliferate into mature cells of various types. Has morph. charac. specific to lineage
Embryo Hematopoiesis
wk 3: fetal yolk sac
then, liver
2nd trimester: spleen
at term: BM
<4yr: all bone cavities
adults: axial skeleton, proximal long bone
stroma includes:
fat cells, macrophages, endothelial cells, fibroblasts
Non-lineage specific Growth Factors (for hematopoiesis)
Act on pluripotent & multipotent SC's. initiate self-renewal & differentiation
-IL-3
-GM-CSF
Lineage specific Growth Factors (for hematopoiesis)
G-CSF
M-CSF
IL-5
EPO
TPO (thrombopoietin)
Erythropoiesis
proerythroblast
basophilic erythroblast
polychromatophilic erythroblast (last stage capable of division) 
orthochromatophilic erythroblast
reticulocyte
mature RBC
proerythroblast
basophilic erythroblast
polychromatophilic erythroblast (last stage capable of division)
orthochromatophilic erythroblast
reticulocyte
mature RBC
Proerythroblast (pronormoblast)
LARGE cells w/ intense blue cytoplasm & round nucleus w/ few NUCLEOLI
-committed stem cell
LARGE cells w/ intense blue cytoplasm & round nucleus w/ few NUCLEOLI
-committed stem cell
Basophilic Erythroblast (normoblast)
intense darker blue cytoplasm, condensed nuclear chromatin, WITHOUT nucleoli
intense darker blue cytoplasm, condensed nuclear chromatin, WITHOUT nucleoli
Polychromatophilic Erythroblast
grayish cytoplasm (Hgb production), smaller condensed nucleolus
-last stage capable of division 
-first cell to make Hgb*
grayish cytoplasm (Hgb production), smaller condensed nucleolus
-last stage capable of division
-first cell to make Hgb*
Orthochromatophilic Erythroblast
reddish cytoplasm, very small condensed nucleus
reddish cytoplasm, very small condensed nucleus
Reticulocyte
after orthochromic normoblast extrudes nucleus. 
retains mitochondria and polyribosomes (Hgb produc)
-first immature RBC
-remnants of RNA = "reticular"
after orthochromic normoblast extrudes nucleus.
retains mitochondria and polyribosomes (Hgb produc)
-first immature RBC
-remnants of RNA = "reticular"
mature RBC
after reticulocyte loses capacity for aerobic metabolism and Hgb synthesis 
a couple days after leave BM 
-120 day lifespan
after reticulocyte loses capacity for aerobic metabolism and Hgb synthesis
a couple days after leave BM
-120 day lifespan
Granulopoiesis
myeloblast
promyeloblast
myelocyte
metamyelocyte
band
neutrophil
myeloblast
promyeloblast
myelocyte
metamyelocyte
band
neutrophil
Myeloblast
large cell, high N:C ratio
-nucleus: delicate chromatin pattern w/ few nucleoli
large cell, high N:C ratio
-nucleus: delicate chromatin pattern w/ few nucleoli
Promyelocyte
similar to myeloblast appearance, except cytoplasm contains primary (purple) granules
similar to myeloblast appearance, except cytoplasm contains primary (purple) granules
Myelocyte
*last stage capable of division. 
-nucleus: smaller, condense, lacks nucleoli, may be eccentrically located
-cytoplasm: secondary (pink) granules
-granules specific to neutrophils/eosinophils/basophils
*last stage capable of division.
-nucleus: smaller, condense, lacks nucleoli, may be eccentrically located
-cytoplasm: secondary (pink) granules
-granules specific to neutrophils/eosinophils/basophils
Metamyelocyte
kidney-shaped nucleus, pink cytoplasm
kidney-shaped nucleus, pink cytoplasm
Band
horseshoe nucleus, pink cytoplasm
horseshoe nucleus, pink cytoplasm
Neutrophil
highly condense, loculated nucleus
highly condense, loculated nucleus
-first line of defense against microorganisms
-lysosomal enzymes digest ingested bacteria
Monocytopoiesis
monoblasts -> monocytes, leave bloodstream -> part of mononuclear phagocyte system
Megakaryocytopoiesis
-megakaryocytes mature into multilobed giant cells (endomitotic divisions) 
-cytoplasm becomes granular, released into BM sinusoids in ribbons that contain platelets
-megakaryocytes mature into multilobed giant cells (endomitotic divisions)
-cytoplasm becomes granular, released into BM sinusoids in ribbons that contain platelets
Lymphopoiesis
B-cells: differentiate in BM, then to lymphoid organs
T-cells: differentiate in thymus, then to lymphoid organs
nl Adult BM
-50% fat cells
-myeloid:erythroid = 2:1 to 7:1
-megakaryocytes: 2-5 per high power field 
-plasma cells <3%
-lymphocytes <20%
-50% fat cells
-myeloid:erythroid = 2:1 to 7:1
-megakaryocytes: 2-5 per high power field
-plasma cells <3%
-lymphocytes <20%
Cellular Components of Blod
-Erythrocytes
-Granulocytes (basophils, neutrophils, eosinophils)
-Monocytes
-Lymphocytes
-Platelets