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17 Cards in this Set

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hallmarks of AHC dz

-pure weakness, sensory OK


-LMN (ALS is the only one with also UMN)


-fasciculations

UMN lesions in ALS

corticospinal & corticobulbar tracts

pseudobulbar palsy: degen of corticobulbar tract

emotional lability, dysarthria, dysphagia

LMN in ALS

AHC & brainstem degen (primarily motor nuclei in medulla)

motor nuclei: nucleus ambiguous & hypoglossal nucleus

dysarthria/dysphagia (BULBAR PALSY)

low amplitude CMAP, but NORMAL SNAP

ALS

fasciculations/fibrillations & large motor unitis

ALS

how are bowel & bladder in ALS?

preserved

why is it that eye movements are ok until very late in ALS?

higher brain stem motor units are preserved

where are the anterior horn cells?

skinny part of butterfly (fat part is preserved-sensory)

what happens if you have EXCESSIVE GLUTAMATE which overstimulates NMDAreceptors--->causing overload of Ca++ in the post synaptic neuron?

cell death: damanage/death after stroke, seizures, ALS

reflexes in ALS

up and down

reflexes in peripheral neuropathy

decreased

reflexes in MG & myopathy

normal

spastic & flaccid weakness

ALS

distal/flaccid weakness

PN

Dx of West Nile

WNV-specific IgG and IgM antibodies