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44 Cards in this Set

  • Front
  • Back
erythropoiesis
production of rbcs
hematopoiesis
production of blood cells
what is it called when hbg has a decreased oxygen affinity
right shift
what is it called when hbg has a increased oxygen affinity
left shift
what are the 3 hemoglobin types
hbg a
hbg a2
hbg f
what are they composed of
hbg a= 2 alpha & 2 beta
hbg a2= 2 alpha & delta
hbg f= 2 alpha & gamma
blister cell
rbc thatt contains one or more vacuoles that resemble a blister
helmet cell (shiztocyte)/shistocyte
a cell that looks like football helmet, or may just be a fragment of rbc, seen in hemolytic anemia due to severe burns, and uremia
sickle cell/ drepanocyte
sickle cell anemia
stomatocytes
rbc an oval area of palor, seen in alcholism, hereditary stomatocitosis, and rh null disease
target cells/codocyte
looks like bullseye, seen in hbg c, and s, liver disease, thalassemia and ida
teardrop cell/dacryocyte
shaped like tear or pear, seen in myelofibrosis with myeloid metaplasia, thalassemias
siderocytes/sideroblasts
iron in rbc, when stained with wright stain is called pappenheimer bodies
basophillic stippling
associated with impaired heme synthesis, seen in thalassemia and lead posioning
cabot ring
looks like figure 8, seen in lead poisoning and pernicious anemia
heinz bodies
only seen in supervital methlyene blue stain, associated with abnormal hemeglobins, g6pd deficiency and alpha thalassemia
howell jolly bodies
nuclear remnants of dna, seen in splenectomy, megaloblastic anemia and hemolytic anemia
when do specific (secondary) granules appear in wbc
myelocyte stage
neutrophils
50% in circulation
50% adhere to wall of blood vessels(marginal pool)
eosinophils
inflammatory reactions and parasitic infections
basophils
systemic allergic reactions, high concentratons of histamines and heparin
monocytes
mature into macrophages
t lymphs
live several months to several years, important for antigenic memory, apart of cellular immunity
b lymphs
live for a few days, apart of humoral immunity
toxic granulation
seen primarily in neutrophils, seen in infections, drug poisoning and burns
dohle bodies
seen in cytoplasm of neutrophils, seen in infections, poisoning(chemo), burns and dohle like inclusions in may hegglin anomaly
hypersegmentation
6 or more lobes, seen in megaloblastic anemias, chronic infections and inheirited representing abnormal cellular maturation
pelger-huet anomaly
genetic failure of neutrophils nucleus to segment properly, all the segs fail to segment properly making this one easy to identify
may hegglin anomaly
causes large dohle like inclusions in neutrophils, platelets abnormally large&bizarre shapes,may experience bleeding problems
chekiak-higashi syndrome
rare fatal hereditary disorder found in kids, makes them prone to infections because of neutrophils impaired function, neut,monos,and lymphs are affected with large granules which are bluish purple in neuts, and reddish purple in the others
alder-reilly anomaly
heavy azurophillic granulation seen primarily in neutro, eos,
and basos, caused by mucopolysaccharide disorder seen in patients with hurler and hunter syndromes
auer rods
rod like bodies that stain reddish purple and found in cytoplasm of blast cells in acute myelogenous and monocytic leukemias
barr body
nuclear chromatin projection seen in females with a second x chromosome
degenerated neutrophil with pyknotic nucleus
very round segments representing nuclear degeneration, cell death
vacuolated neutrophil
neutrophil with vacuoles, due to active phagocytosis
mott cell
plasma cell with vacuoles
smudge cell
cellular artifact created when preparing slide due to cellular fragility, its the nucleus without cytoplasm
atypical platelets
most often seen in myeloproliferative disorders
chemotaxis
directed movement of neutrophils, lymphs, and monos by chematic factors
opsonization
antigens coated with antibodies which usually leads to phagacytosis
necrotaxis
attraction to dead or dying things
necrophagocytosis
ingestion of dying cells and cellular debris
large lymphs
nucleus is round/oval, may be indented, chromatin is condensed to deeply condensed. cytoplasm sky blue, may have few azurophilic granules. rbcs generally indent cytoplasm
monos
nucleus is more variable, horeshoe or kidney shaped. folds or clefts brainlike convolutions. chromatin is fine lacy, cytoplasm blue gray and may have pseudopods.